Evidence for Population-Specific Positive Selection on Immune Genes of Anopheles gambiae
نویسندگان
چکیده
منابع مشابه
Evidence for Population-Specific Positive Selection on Immune Genes of Anopheles gambiae
Host-pathogen interactions can be powerful drivers of adaptive evolution, shaping the patterns of molecular variation at the genes involved. In this study, we sequenced alleles from 28 immune-related loci in wild samples of multiple genetic subpopulations of the African malaria mosquito Anopheles gambiae, obtaining unprecedented sample sizes and providing the first opportunity to contrast patte...
متن کاملPopulation genetics of Plasmodium resistance genes in Anopheles gambiae: no evidence for strong selection.
Anopheles mosquitoes are the primary vectors for malaria in Africa, transmitting the disease to more than 100 million people annually. Recent functional studies have revealed mosquito genes that are crucial for Plasmodium development, but there is presently little understanding of which genes mediate vector competence in the wild, or evolve in response to parasite-mediated selection. Here, we u...
متن کاملLocus- and population-specific selection and differentiation between incipient species of Anopheles gambiae.
Anopheles gambiae, the primary mosquito vector of malaria in sub-Saharan Africa, is divided into 2 sympatric incipient species known as M form and S form. Recent genomic analysis of each form revealed that differentiation between forms is clustered into 3 unlinked regions of the genome. Here, we expand the investigation of these "genomic islands of speciation" to multiple populations, including...
متن کاملNo evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s.
Human malaria causes nearly a million deaths in sub-Saharan Africa each year. The evolution of drug-resistance in the parasite and insecticide resistance in the mosquito vector has complicated control measures and made the need for new control strategies more urgent. Anopheles gambiae s.s. is one of the primary vectors of human malaria in Africa, and parasite-transmission-blocking vaccines targ...
متن کاملAnopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection
BACKGROUND It has long been the goal of vector biology to generate genetic knowledge that can be used to "manipulate" natural populations of vectors to eliminate or lessen disease burden. While long in coming, progress towards reaching this goal has been made. Aiming to increase our understanding regarding the interactions between Plasmodium and the Anopheles immune genes, we investigated the p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2012
ISSN: 2160-1836
DOI: 10.1534/g3.112.004473